Oral chemotherapy for colon cancer

Chemotherapy chemo is often used to treat colorectal cancer. It's the use of drugs to kill cancer cells. How is chemotherapy given? You can get chemotherapy in different ways. Drugs are put right into your blood through a vein or you take them by mouth. The drugs enter your bloodstream and reach all areas of your body.
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Oral versus intravenous chemotherapy for colorectal cancer

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Oral versus intravenous chemotherapy for colorectal cancer | Cochrane

Oral versus intravenous chemotherapy for colorectal cancer Background Intravenous IV fluoropyrimidines are an essential part of chemotherapy treatment for colorectal cancer CRC. Patients prefer tablets as long as they work as well and are as safe as IV treatment, because they are easier to take and are more convenient. Review question We compared the effects of oral and IV fluoropyrimidine chemotherapy in patients with CRC who were treated with the aim of cure, or who were treated with palliative chemotherapy because the cancer could not be removed by surgery or was metastatic it had spread from the place where it originated to other places in the body. Study characteristics The evidence is current to June We identified 44 randomised controlled trials involving 23, patients which compared oral and IV fluoropyrimidines.
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Oral Chemotherapeutic Agents for Colorectal Cancer

The most common side effects at this dose were diarrhea, nausea, fatigue, and anorexia. Four patients had a partial response and further development work is underway. Eniluracil is not a prodrug of 5-FU or an anticancer agent, rather, it potentiates the effects of 5-FU by causing virtually complete inhibition of DPD. In tumor samples collected at surgery, there was complete suppression of the tumor DPD catalytic activity. There was also complete suppression of systemic DPD activity in mononuclear cells.
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