Penetration of fluoroquinolones into prostate

Immediate access to this article To see the full article, log in or purchase access. She completed an American Society of Health System Pharmacists general residency and a fellowship in infectious diseases and microbiology at Northwestern Memorial Hospital, Chicago Address correspondence to Catherine M. Reprints are not available from the authors.
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Quinolones: A Comprehensive Review

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Penetration of antimicrobial agents into the prostate. - Semantic Scholar

Advanced Search Abstract Prostatitis is characterized by voiding symptoms and genitourinary pain and is sometimes associated with sexual dysfunction. The causes and treatment of nonbacterial prostatitis are largely unknown, but bacterial prostatitis is caused by infection with uropathogens, especially gram-negative bacilli, although infection is sometimes due to gram-positive and atypical microorganisms. Acute bacterial prostatitis is easily diagnosed by abrupt urogential and often systemic symptoms, along with bacteriuria and treated by systemic antibiotic therapy. Chronic bacterial prostatitis is characterized by prolonged or recurrent symptoms and relapsing bacteriuria; diagnosis traditionally requires comparing urinary specimens obtained before with specimens obtained after prostatic massage. Treating chronic bacterial prostatitis requires prolonged therapy with an antibiotic that penetrates the prostate ie, one with high lipid solubility, a low degree of ionization, high dissociation constant, low protein binding, and small molecular size. We review recent pharmacological and clinical data on treating bacterial prostatitis. Prostatitis is a common syndrome that usually presents with voiding symptoms irritative or obstructive and pain genitourinary, pelvic, or rectal and is sometimes associated with sexual dysfunction eg, ejaculatory discomfort and hematospermia.
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The pharmacokinetics and tissue penetration of the fluoroquinolones.

Serum and prostatic tissue concentrations of moxifloxacin in patients undergoing transurethral resection of the prostate. Because of its broad spectrum of activity, the group 4 fluoroquinolone moxifloxacin might be a suitable antibiotic for treatment of bacterial prostatitis. The aim of this prospective study was to investigate the penetration of moxifloxacin into prostatic tissue in patients with benign prostatic hyperplasia. Patients received a single dose of moxifloxacin mg in an 1 hour lasting infusion ml for perioperative prophylaxis before undergoing transurethral resection of the prostate TURP.
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