Some authors began to think of endocrine therapy as an alternative approach, especially for bca patients with inoperable disease and contraindications to chemotherapy. Endocrine therapy consisted of ovarian suppression using a gnrh analog. After obtaining a postmenopausal level of circulating estradiol, the ai letrozole was added for at least 3 months. Estradiol and gonadotrophin levels were checked monthly to verify ovarian suppression. At the time of surgery, all tumours were still er-positive; downregulation of pgr was observed in 26 patients. Endocrine therapy also induced downregulation of proliferative activity:
Hormonal Therapy for Pre-menopausal Women with Early Stage Breast Cancer
Hormonal Therapy for Pre-menopausal Women with Early Stage Breast Cancer - Stop Cancer Fund
Save as Favorite Sign in to receive recommendations Learn more Aromatase inhibitors stop the production of estrogen in postmenopausal women. This means that less estrogen is available to stimulate the growth of hormone-receptor-positive breast cancer cells. There are three aromatase inhibitors: Aromatase inhibitors can't stop the ovaries from making estrogen, so aromatase inhibitors are mainly used to treat postmenopausal women.